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. 2016 Jul 22;113(32):9015–9020. doi: 10.1073/pnas.1603883113

Fig. S4.

Fig. S4.

Knockdown of HSPA12A restores MAL3-101 sensitivity to RMS13-R cells. (A) Parental RMS13 and resistant RMS13-R cells were transfected with siRNA as indicated, and the change in HSPA12A transcript was measured by qPCR (data show mean fold-change ± SEM). The difference between RMS13 treated with control siRNA (siCTL) and RMS13-R treated with either siRNA targeting HSPA12A was not significant by two-tailed t test (P = 0.13 for siRNA #1 and 0.26 for siRNA #2). (B) RMS13 and RMS13-R lines transfected with siRNAs as in A were treated with increasing amounts of MAL3-101, and viability was measured using CellTiter-Glo. Error bars show SEM from three independent replicates.