Table 2. Mean Tractography Values.

	Younger controls		Younger patients		Older controls		Older patients
	Males (N=40)	Females (N=23)	Males (N=47)	Females (N=18)	Males (N=29)	Females (N=19)	Males (N=30)	Females (N=18)
Fractional anisotropy
Anterior thalamic radiation	0.479 (0.028)	0.469 (0.028)	0.480 (0.022)	0.456 (0.034)	0.456 (0.022)	0.472 (0.027)	0.472 (0.039)	0.451 (0.028)
Cingulum	0.555 (0.042)	0.541 (0.056)	0.559 (0.043)	0.504 (0.053)	0.547 (0.043)	0.549 (0.049)	0.557 (0.051)	0.510 (0.055)
Corticopontine	0.601 (0.025)	0.603 (0.024)	0.603 (0.020)	0.597 (0.020)	0.589 (0.023)	0.590 (0.019)	0.592 (0.034)	0.578 (0.025)
Inferior fronto-occipital fasciculus	0.557 (0.026)	0.553 (0.024)	0.556 (0.019)	0.544 (0.027)	0.536 (0.024)	0.542 (0.026)	0.533 (0.036)	0.511 (0.025)
Inferior longitudinal fasciculus	0.569 (0.028)	0.569 (0.029)	0.561 (0.029)	0.549 (0.035)	0.551 (0.031)	0.547 (0.039)	0.542 (0.030)	0.519 (0.038)
Superior longitudinal fasciculus	0.531 (0.032)	0.528 (0.031)	0.526 (0.027)	0.501 (0.035)	0.516 (0.027)	0.521 (0.036)	0.520 (0.035)	0.489 (0.036)
Uncinate fasciculus	0.530 (0.033)	0.514 (0.029)	0.534 (0.021)	0.509 (0.024)	0.514 (0.029)	0.527 (0.025)	0.526 (0.039)	0.499 (0.030)
Genu of the corpus callosum	0.560 (0.031)	0.552 (0.028)	0.562 (0.024)	0.535 (0.032)	0.530 (0.030)	0.540 (0.030)	0.532 (0.32)	0.505 (0.020)
Splenium of the corpus callosum	0.612 (0.029)	0.599 (0.031)	0.619 (0.033)	0.596 (0.026)	0.599 (0.030)	0.588 (0.024)	0.600 (0.036)	0.555 (0.049)
Mean diffusivity
Anterior thalamic radiation	0.751 (0.028)	0.764 (0.026)	0.761 (0.023)	0.778 (0.033)	0.771 (0.028)	0.755 (0.032)	0.760 (0.075)	0.778 (0.031)
Cingulum	0.722 (0.032)	0.726 (0.030)	0.728 (0.029)	0.745 (0.036)	0.722 (0.027)	0.716 (0.038)	0.717 (0.041)	0.739 (0.039)
Corticopontine	0.718 (0.027)	0.718 (0.025)	0.718 (0.020)	0.725 (0.027)	0.726 (0.027)	0.711 (0.023)	0.715 (0.043)	0.728 (0.027)
Inferior fronto-occipital fasciculus	0.780 (0.028)	0.782 (0.027)	0.783 (0.023)	0.794 (0.026)	0.802 (0.032)	0.787 (0.035)	0.801 (0.058)	0.820 (0.039)
Inferior longitudinal fasciculus	0.782 (0.034)	0.783 (0.025)	0.785 (0.032)	0.796 (0.029)	0.799 (0.038)	0.784 (0.057)	0.791 (0.051)	0.810 (0.039)
Superior longitudinal fasciculus	0.707 (0.027)	0.707 (0.023)	0.708 (0.023)	0.724 (0.032)	0.716 (0.029)	0.707 (0.042)	0.718 (0.055)	0.732 (0.041)
Uncinate fasciculus	0.777 (0.028)	0.786 (0.030)	0.782 (0.022)	0.797 (0.023)	0.779 (0.025)	0.769 (0.034)	0.770 (0.045)	0.784 (0.038)
Genu of the corpus callosum	0.832 (0.038)	0.840 (0.044)	0.851 (0.070)	0.860 (0.044)	0.870 (0.044)	0.829 (0.035)	0.865 (0.087)	0.887 (0.048)
Splenium of the corpus callosum	0.815 (0.070)	0.852 (0.095)	0.827 (0.109)	0.858 (0.065)	0.861 (0.071)	0.871 (0.072)	0.888 (0.122)	0.938 (0.140)
Axial diffusivity
Anterior thalamic radiation	1.18 (0.029)	1.19 (0.041)	1.20 (0.029)	1.20 (0.028)	1.18 (0.038)	1.18 (0.040)	1.18 (0.072)	1.18 (0.038)
Cingulum	1.23 (0.056)	1.22 (0.059)	1.24 (0.048)	1.21 (0.059)	1.22 (0.055)	1.21 (0.064)	1.22 (0.057)	1.20 (0.036)
Corticopontine	1.28 (0.029)	1.28 (0.035)	1.28 (0.037)	1.29 (0.046)	1.28 (0.043)	1.25 (0.040)	1.25 (0.062)	1.26 (0.037)
Inferior fronto-occipital fasciculus	1.32 (0.035)	1.32 (0.038)	1.33 (0.034)	1.33 (0.026)	1.33 (0.041)	1.32 (0.036)	1.32 (0.043)	1.33 (0.034)
Inferior longitudinal fasciculus	1.35 (0.046)	1.35 (0.037)	1.34 (0.048)	1.34 (0.029)	1.35 (0.052)	1.32 (0.052)	1.32 (0.065)	1.32 (0.044)
Superior longitudinal fasciculus	1.16 (0.038)	1.16 (0.027)	1.16 (0.030)	1.15 (0.024)	1.16 (0.040)	1.14 (0.042)	1.17 (0.063)	1.15 (0.037)
Uncinate fasciculus	1.29 (0.036)	1.29 (0.050)	1.30 (0.031)	1.30 (0.032)	1.27 (0.040)	1.27 (0.050)	1.27 (0.050)	1.26 (0.043)
Genu of the corpus callosum	1.42 (0.042)	1.42 (0.053)	1.45 (0.068)	1.42 (0.052)	1.43 (0.037)	1.37 (0.049)	1.42 (0.093)	1.42 (0.052)
Splenium of the corpus callosum	1.46 (0.090)	1.49 (0.116)	1.48 (0.124)	1.50 (0.089)	1.51 (0.097)	1.50 (0.092)	1.54 (0.148)	1.55 (0.150)
Radial diffusivity
Anterior thalamic radiation	0.536 (0.033)	0.550 (0.029)	0.542 (0.026)	0.569 (0.043)	0.564 (0.029)	0.544 (0.035)	0.551 (0.078)	0.574 (0.034)
Cingulum	0.468 (0.042)	0.480 (0.052)	0.470 (0.042)	0.515 (0.050)	0.474 (0.039)	0.515 (0.050)	0.466 (0.053)	0.510 (0.058)
Corticopontine	0.438 (0.032)	0.435 (0.027)	0.436 (0.021)	0.442 (0.026)	0.451 (0.027)	0.441 (0.022)	0.446 (0.042)	0.460 (0.030)
Inferior fronto-occipital fasciculus	0.507 (0.033)	0.511 (0.030)	0.510 (0.025)	0.525 (0.035)	0.537 (0.035)	0.523 (0.035)	0.541 (0.063)	0.568 (0.042)
Inferior longitudinal fasciculus	0.500 (0.037)	0.500 (0.033)	0.508 (0.037)	0.522 (0.041)	0.522 (0.043)	0.517 (0.065)	0.526 (0.050)	0.553 (0.048)
Superior longitudinal fasciculus	0.480 (0.034)	0.482 (0.032)	0.484 (0.029)	0.511 (0.042)	0.493 (0.034)	0.488 (0.049)	0.494 (0.057)	0.523 (0.048)
Uncinate fasciculus	0.521 (0.036)	0.536 (0.031)	0.520 (0.026)	0.546 (0.028)	0.531 (0.031)	0.517 (0.033)	0.521 (0.050)	0.546 (0.042)
Genu of the corpus callosum	0.541 (0.045)	0.550 (0.046)	0.554 (0.074)	0.578 (0.048)	0.593 (0.053)	0.555 (0.040)	0.588 (0.086)	0.622 (0.048)
Splenium of the corpus callosum	0.493 (0.066)	0.531 (0.089)	0.497 (0.105)	0.537 (0.058)	0.538 (0.065)	0.558 (0.067)	0.564 (0.113)	0.632 (0.142)

Notes: Data are presented for descriptive purposes only (see text for a description of the statistical analysis plan). SDs are in parentheses. FA values are dimensionless and multiplied by 1000. Axial, radial, and mean diffusivity units are 10⁻³ mm²/s.