Figure 3.

Main effect of demand for control. In both smokers (orange) and non-smokers (gray), a main effect of DEMAND was observed. (a) Within the ROIs of the cognitive control network (Supplementary Figure S1), increasing demand for control led to increased activation across multiple ROIs. (b) Exploratory whole-brain analysis showed similar results in R aINS and L pc gyr and additionally showed a monotonic decrease in activation in both groups in R sgACC as demand for control increased. Error bars reflect SEM. L aINS, left anterior insula; L ipl, left intraparietal lobule; L pc gyr, left precentral gyrus; R cing, right cingulate gyrus; R aINS, right anterior insula; R sgACC, right subgenual anterior cingulate cortex.