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. 2016 Jul 12;29(8):1325–1334. doi: 10.1021/acs.chemrestox.6b00143

Figure 3.

Figure 3

BaP metabolism catalyzed by human P450 1A1 reconstituted with POR or CBR with or without cytochrome b5 (cyt b5). Columns show the sum of individual BaP metabolites formed by P450 1A1 (BaP-3-ol, BaP-9-ol, BaP-1,6-dione, BaP-3,6-dione, and the unknown metabolite Mx) Incubations were carried out in the presence of NADPH or NADH. ΔΔΔP < 0.001 (Student’s t-test), significantly different from incubations without cytochrome b5; ***P < 0.001 (Student’s t-test), significantly different from incubations with NADPH as cofactor.