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. 2016 Apr 29;44(Web Server issue):W217–W225. doi: 10.1093/nar/gkw342

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© The Author(s) 2016. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 5. — A heterologous biosynthesis pathway to produce naringenin from L-tyrosine in an E. coli host. (A) The structure of an experimentally derived biosynthesis pathway (29). The EC number for each reaction is indicated below the arrow. The KEGG compound ID of each metabolite is framed in red. The abbreviations are: tyrosine ammonia lyase (TAL); 4-coumarate:CoA ligase (4CL); chalcone synthase (CHS) and chalcone isomerase (CHI). (B) The information of the top-ranked biosynthesis pathway in MRE.