Table 1. Loop-prediction performance of RCD+ and other state-of-the-art methods.

		Nativea					Modeling
		HLPb	Galaxy	RCD+			HLP	Galaxy	Rosetta	RCD+
Lengthc		Std.	PS2	1d	5	20	SS	PS2	NGK	1	5	20
	Median	0.6	0.6	0.5	0.3	0.3	0.9	1.1	0.4	0.5	0.4	0.4
8	Average	1.2	0.9	0.6	0.5	0.4	1.3	1.3	0.5	0.8	0.7	0.6
	Sigma	1.5	0.7	0.3	0.3	0.2	1.5	1.0	0.3	1.0	1.0	0.8
	#e	13	14	17	18	19	11	9	17	15	18	18
	Median	0.6	1.4	0.6	0.4	0.4	0.9	1.6	0.8	0.6	0.6	0.5
12	Average	1.2	1.6	1.0	0.9	0.7	1.4	2.1	1.7	1.4	0.8	0.8
	Sigma	1.2	1.3	1.7	1.0	1.0	1.4	1.7	1.8	1.6	0.9	0.9
	#e	12	7	16	16	17	11	4	11	13	17	17

^aSampling scenarios: (i) Native, the side-chains of the loop environment are kept, or (ii) Modeling, include the refinement of the loop environment side-chains.

^bHLP, HLP-SS, Galaxy-PS2 and Rosetta-NGK Root Mean Squared Deviations (RMSDs) were taken from Supplementary Tables S1, S2, S4 and S5 of (8) and calculated considering the main-chain atoms N, C_α, C and O.

^cNumber of residues of the loop.

^dRMSD of the lowest Rosetta-energy loop predicted with RCD+ together with the best RMSD of the 5 and 20 loops of lowest Rosetta-energies.

^eNumber of sub-angstrom cases.