Spatial expression pattern of zswim5. Zswim5 was first detected at the dorsal blastopore lip in early gastrula (A, B), and then was preferentially expressed in the future neural plate at later gastrula stages (C). At neurula stages, zswim5 signals were restricted at the anterior neural plate, partially covering the NC region (D–F). Zswim5 was mainly expressed at anterior neural tube and lens at tail bud and tadpole stages (G, H).