. 2016 Aug 17;16:71. doi: 10.1186/s12903-016-0261-5

Table 2.

Characteristics of the randomized trials reporting on the treatment of periodontal intrabony defects

Authors and publication year	Design	Country	Patients	Sites	Treatment		Site		Defects (walls)	Follow-up	Effect	Evaluation
Authors and publication year	Design	Country	Patients	Sites	Intervention	Control	Intervention	Control	Defects (walls)	Follow-up	Effect	Evaluation
Gupta G et al. 2014 [34]	Split-mouth	India	10	20	PRP + HA	HA	10	10	1, 2, 3	12 mo	Positive	BOP, PD, CAL,
Okuda K et al. 2005 [11]	Parallel	Japan	70	70	PRP + HA	HA	35	35	2, 3	12 mo	Positive	GI, BOP, PD, CAL, GR, DF
Hanna R et al. 2004 [35]	Split-mouth	US	13	26	PRP + BDX	BDX	13	13	2, 3	6 mo	Positive	PD, CAL, GI, PI, REC, BOP
Ouyang XY et al. 2006 [36]	Split-mouth	China	10	17	PRP + ABB	ABB	9	8	2, 3	12 mo	Positive	PI, PD, CAL, REC, Bone defect fill
Döri et al. 2009 [37]	Parallel	Hungary	30	30	PRP + ABB	ABB	15	15	1,2	13 mo	None	PD, GR, CAL, PI, GI, BOP,
Demir et al. 2007 [38]	Parallel	Turkey	29	29	PRP + BG	BG	15	14	1, 2, 3	9 mo	None	PD, CAL, GR, PI, GI, BOP,
Agarwal et al. 2014 [39]	Split-mouth	India	24	48	PRP + DFDBA	DFDBA	24	24	2, 3	12 mo	Positive	PD, CAL, REC
Piemontese et al. 2008 [40]	Parallel	India	60	60	PRP + DFDBA	DFDBA	30	30	2, 3	12 mo	Positive	GI, PI, PD, CAL, BOP, REC,
Harnack et al. 2009 [41]	Split-mouth	Germany	22	44	PRP + β-TCP	β-TCP	22	22	2	6 mo	Positive	GI, PI, PD, CAL, BOP,
Özdemir et al. 2012 [ 43]	Parallel	Turkey	14	28	PRP + β-TCP	β-TCP	14	14	2,3	7 mo	None	PD, CAL, GI, BOP,
Kaushick et al. 2007 [43]^\	Split-mouth	India	10	20	PRP + β-TCP + HA	β-TCP + HA	10	10	2, 2–3, 3	6 mo	Positive	PD, CAL, GI, PI
Christgau et al. 2006 [44]	Split-mouth	Germany	25	50	PRP + β-TCP + GTR	β-TCP + GTR	25	25	2, 2–3, 3	12 mo	None	PI, GI, BOP, PD, GR, CAL,
Döri, Huszar et al. 2007 [45]	Parallel	Hungary	24	24	PRP + ABB + GTR	ABB + GTR	12	12	1-2, 2	12 mo	None	BOP, PD, CAL,
Döri et al. 2007 [46]	Parallel	Hungary	30	30	PRP + NBM + GTR	NBM + GTR	15	15	1-2, 2, 3	12 mo	None	PD, GR, CAL, PI, GI, BOP,
Döri et al. 2008 [47]	Parallel	Hungary	28	28	PRP + β-TCP + GTR	β-TCP + GTR	14	14	1-2, 2, 3	12 mo	Positive	PD, CAL, PI, GI, BOP, GR

Intervention PRP group, HA hydroxyapatite, BDX bovine-derived xenograft, ABB anorganic bovine bone, BG bioactive glass, DFDBA demineralized freeze-dried bone allograft, β-TCP β-tricalcium phosphate, NBM natural bone mineral