FIG 2.
Memory CD4 T cells from HIV-1-infected subjects displayed reduced protection from apoptosis upon IL-2 stimulation. (A) Fas-mediated apoptosis of memory CD4 T cells for PHI, CHI, and HIVfree subjects in the presence or absence of IL-2 treatment. This was calculated using the following formula: percent apoptosis of cells treated with anti-Fas antibody − percent apoptosis of anti-Fas-untreated cells. (B) Ex vivo percentage of CD95-positive memory CD4 T cells. (C) Levels of apoptosis protection when cells were treated with IL-2. In panels A to C, data are for 6 subjects in each group. (D) Correlation between the level of apoptosis protection with IL-2 and the ex vivo frequency of memory CD4 T cells from all subjects (n = 18). *, 0.05 > P > 0.01; **, 0.01 > P > 0.001.