FIG 6.
ART restores proper IL-2 signaling in memory CD4 T cells by reducing ROS and Kyn levels. (A) Clinical features of 5 HIV-1-infected patients in each subject group at the pre- and on-ART longitudinal time points. d, number of days; undetectable#, the VL was <40 copies/ml. (B to D) Measurement of Kyn (B), ROS (C), and IL-2-induced pSTAT5 (D) levels for all subject groups. In panels A to D, data are for 5 subjects in each group. (E) Correlations between Kyn and ROS (i) or IL-2-induced pSTAT5 (ii) levels for subjects pre-ART, subjects on ART, and HIV-1free subjects (n = 15). *, 0.05 > P > 0.01; **, 0.01 > P > 0.001.