FIG 1.
APOBEC3 does not protect mice from intraocular HSV-1 infection. (A and B) HSV-1 strain McKrae (106 PFU) was intraocularly applied to mice of the indicated genotypes, and at 5.7 dpi, their eyes (A) and spleens (B) were harvested and DNA was isolated for qPCR analysis (n = 5 for all genotypes). (C and D) An additional mouse of each genotype as well as Tmem173 was inoculated via the same route with 106 or 107 PFU of HSV-1, and infection in eyes (C) and spleen (D) was analyzed. Although not included in the calculation of the geometric mean, mice with values of 0 are shown on the plot. NS, not significantly different by one-way analysis of variance (ANOVA); **, P ≤ 0.002; ****, P ≤ 0.0001 (by two-tailed unpaired t test.