FIG 2.

In vitro neutralization by CD4i antibodies on CD4i-resistant HIV-1 isolates. (A) HIV-1 isolates BG505 and ConC were preincubated for 1 h with various concentrations of VRC01, E51, 412d, and 17b. TZM-bl cells were then added and incubated for 48 h. Infection was measured by the percent luciferase expression in the absence of inhibitor. (B) Similar to panel A except that BG505 or ConC was preincubated for 1 h with a fixed total concentration (0.033 μg/ml for BG505 or 0.045 μg/ml for ConC) but various ratios of VRC01-E51 mixtures. (C) Similar to panel A except that BG505 or ConC was preincubated for 1 h with a fixed total concentration (0.033 μg/ml for BG505 or 0.045 μg/ml for ConC) but various ratios of VRC01-412d mixtures. Error bars represent SEM.