FIG 10.

Antibody immune responses (determined in ELISAs) to GPCMV and specific viral glycoprotein complexes (gB, gH/gL, and gM/gN) in DISC GP85-vaccinated guinea pigs. (A) Immune responses of animals vaccinated with DISC GP85 under the R1 or R2 regimen were compared to animals hyperimmunized with wild-type GPCMV. Results shown are means for each group with standard deviations represented by error bars. Statistically significant differences (P < 0.05; Mann-Whitney test) are shown by lowercase italic letters for comparisons as follows: a, hyperimmune versus R1; b, R1 versus R2; c, hyperimmune versus R2. (B) Neutralizing antibody titers on fibroblast cells from hyperimmune sera, compared to those from the R1 and R2 regimens. Statistically significant differences (P < 0.05; Mann-Whitney test) are indicated by lowercase italic letters for comparisons as follows: d, hyperimmune versus R1; e, hyperimmune versus R2.