FIG 8.

Specificity of influenza virus-reactive CD4 and CD8 T cell responses are broad, display protein-specific preferences, and overlay with heterogeneity between individual animals. (A) Magnitudes of total influenza virus-specific T cell responses from individual ferrets sampled from the spleen at 10 dpi with A/California/04/09 (H1N1). CD4⁻ and CD8⁻ indicate depletion of that cell type for selective interrogation of CD8 and CD4 T cell responses, respectively. (B) Magnitude of antigen-specific T cell responses from individual animals. (C) Viral protein-specific T cell responses from the spleen, represented for each ferret as a percentage of the total response.