FIG 1.

Cell-free virus entry determines the fate of infection in DCs. Cell-free viruses can use at least 3 nonexclusive pathways to enter DCs. (A) In the absence of DC-SIGN, viral binding in enriched lipid raft areas could lead to viral membrane fusion at the plasma membrane. Restriction factors in the cytoplasm will prevent viral replication. (B) In the presence of DC-SIGN in lipid rafts, its interaction with viral glycoproteins leads to signaling (shown as a dashed arrow) favoring the productive infection. DC-SIGN triggering leads to viral internalization in ill-identified vesicles (VCCs) (see the text for details), in which viral fusion could occur. (C) If viral capture occurs in the absence of a coreceptor and DC-SIGN, virions are internalized in clathrin-rich endosomes and directed toward degradation.