TABLE 3.
Multivariate analysis of prognostic factors for overall and disease specific survival.
| Variable | OS
|
DSS
|
||||
|---|---|---|---|---|---|---|
| p value | HR | 95% CI | p value | HR | 95% CI | |
| Primary site | ||||||
| Parotid | .001 | 1 | .002 | 1 | ||
| Major glands | 1.006 | 0.9–1.11 | 1.002 | 1.001–3.1 | ||
| Oral cavity | 1.2 | 0.68–3.22 | 1.1 | 2.3–9.1 | ||
| Sinonasal | 3.16 | 1.47–5.76 | 5.26 | 0.9–1.01 | ||
| Margins | ||||||
| Negative | .012 | 1 | .035 | 1 | ||
| Close (<5 mm) | 2.6 | 1.1–17.2 | 2.33 | 1.2–5 | ||
| Positive | 3 | 1.2–4.1 | 4.36 | 1.5–7.9 | ||
| Pathologic T classification | ||||||
| T1 | .3 | NA | NA | .1 | NA | NA |
| T2 | ||||||
| T3 | ||||||
| T4 | ||||||
| Pathologic N classification | ||||||
| N0 | .01 | 1 | .006 | 1 | ||
| N1 | 2.7 | 1.6–6.1 | 3 | 1.4–5.5 | ||
| N2a | 2.7 | 1.05–6.7 | 3.1 | 1.3–6 | ||
| N2b | 2.05 | 1.15–3.5 | 3.1 | 1.36–3.6 | ||
| N2c | 3.8 | 1.6–7.3 | 4.2 | 2.3–7 | ||
| N3 | 6.8 | 2.3–9 | 22.3 | 10–37.5 | ||
| Extracapsular spread | ||||||
| No | .3 | NA | NA | .39 | NA | NA |
| Yes | ||||||
| Treatment | ||||||
| Surgery | .43 | NA | NA | .39 | NA | NA |
| Surgery + RT | ||||||
| Surgery + CRT | ||||||
| Neck dissection extent | ||||||
| I–III/II–III | .2 | NA | NA | .007 | 1 | |
| I–IV/I–V | 3.1 | 1.1–4.8 | ||||
| RND/MRND | 4 | 2.1–6 | ||||
| Contralateral | 4 | 1.9–7.3 | ||||
Abbreviations: OS, overall survival; DSS, disease-specific survival; HR, hazard ratio; 95% CI, 95% confidence interval; RT, radiation therapy; CRT, chemoradiation therapy; RND, radical neck dissection; MRND, modified radical neck dissection.