Table 2.
Inoculated mini-pigs with human rotavirus at different points in maturity
| Age (d) | Number | Inoculum |
Diarrhea1 |
Viral antigen shedding2 |
||||
| Percentage (%) | Average (days happened) | Persistent (d) | Percentage (%) | Average (d) | Persistent (d) | |||
| 3-5 | 3 | G1 HRV | 100 (3/3) | 1 | 3-5 | 100 (3/3) | 1 | 5-7 |
| 3 | G3 HRV | 100 (3/3) | 1 | 3-6 | 100 (3/3) | 1 | 5-7 | |
| 2 | PBS | 0 | 0 | 0 | 0 | 0 | 0 | |
| 30-35 | 3 | G1 HRV | 100 (3/3) | 3 | 3-5 | 100 (3/3) | 1 | 4-7 |
| 2 | PBS | 0 | 0 | 0 | 0 | 0 | 0 | |
| 56-60 | 3 | G1 HRV | 0 | 0 | 0 | 0 | 2 | 2-3 |
| 2 | PBS | 0 | 0 | 0 | 0 | 0 | 0 | |
1
Diarrhea present if daily fecal consistency score ≥ 2, mean cumulative fecal score = ∑ (Daily fecal scores from 1-7 DPI)/n;
2
Determined by FFA assay. HRV: Human rotavirus; DPI: Days post infection.