Skip to main content
. 2016 Aug 21;22(31):6987–7005. doi: 10.3748/wjg.v22.i31.6987

Table 3.

miRNA candidates correlated to anticancer treatment resistance to the drugs in the FOLFIRINOX and nab-paclitaxel/gemcitabine regimens in tissues and cells from solid tumors

Drug miRNA Expression/polymorphism Tumor type Ref.
5-FU miR-21 Overexpression Pancreatic cancer Donahue et al[126], J Surg Oncol 2014
5-FU and irinotecan pri-miR26a-1 rs7372209 polymorphism Colorectal cancer Boni et al[132], Pharmacogenomics J 2011
5-FU and oxaliplatin miR-106a, miR-484, miR-130b Overexpression Colorectal cancer Kjersem et al[143], Mol Oncol 2014
5-FU, paclitaxel and oxaliplatin miR-27a Overexpression Gastric cancer Huang et al[135], J Cell Biochem 2014
5-FU, capecitabine and oxaliplatin miR-625-3p, miR-181b, miR-27b Overexpression Colorectal cancer Rasmussen et al[133], Mol Oncol 2013
Irinotecan and cetuximab miR-345 Overexpression Colorectal cancer Schou et al[144], PLoS One 2014
Oxaliplatin miR-203 Overexpression Colorectal cancer Zhou et al[145], Mol Oncol 2014
Carboplatin and paclitaxel ± sorafenib miR-659-3p Downregulation Melanoma Villaruz et al[136], Clin Epigenetics 2015
Paclitaxel miR-200c Downregulation Ovarian and endometrial cancer Cochrane et al[146], Mol Cancer Ther 2009
Paclitaxel miR-145 Downregulation Ovarian cancer Zhu et al[147], Int J Cancer 2014
Paclitaxel miR-17-5p Downregulation Lung cancer Aggarwal et al[148], Planta Med 2008
Gemcitabine miR-21 Overexpression Pancreatic cancer Hwang et al[127], PLoS One 2010
Giovannetti et al[128], Cancer Res 2010
Caponi et al[129], Ann Oncol 2013
Gemcitabine miR-21, miR-23a, miR-27a Overexpression Pancreatic cancer Frampton et al[131], Gastroenterology 2014