Table 1.

Multi-organ failure after birth asphyxia in randomized therapeutic hypothermia trials

Study	Selective Head CoolCap [8]		Whole-Body NICHD[9]		Whole-body TOBY trial[10]		Selective Head Chinese trial [11]
	Cooled	Control	Cooled	Control	Cooled	Control	Cooled	Control
Increased Liver Enzymes	38%*	53%	20%	15%	NR	NR	35%	28%
Thrombocytopenia	33%	22%	NR	NR	58%	50%	6%	2%
Prolonged coagulation	50%	42%	18%	11%	41%	43%	NR	NR
Hemorrhage/Bleeding	NR	NR	3%	2%	NR	NR	3%	2%
Renal Failure	65%	70%	22%	26%	ND	ND	23%	22%

^*P<0.05 verses control infants;

NR=not reported; ND= none requiring dialysis