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. Author manuscript; available in PMC: 2017 Sep 1.
Published in final edited form as: Surg Pathol Clin. 2016 Sep;9(3):457–473. doi: 10.1016/j.path.2016.04.009

Table 1.

Molecular genetic categories of soft tissue tumors and sarcoma

  1. Sarcomas with simple genome

    • 1.1

      Tumors with chimeric transcription factors and transcriptional deregulation – e.g. vascular tumors

    • 1.2

      Tumors with deregulated kinase signaling – e.g. GIST

    • 1.3

      Tumors driven by oncometabolites (via epigenetic deregulation) – e.g. chondrosarcoma

    • 1.4

      Tumors driven by primary epigenetic deregulation – e.g. chondroblastoma

  2. Sarcomas with complex genome

    • 2.1

      Tumors with characteristic copy number alterations – e.g. DDLPS

    • 2.2

      Tumors with highly complex karyotypes – e.g. osteosarcoma