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. Author manuscript; available in PMC: 2017 Apr 1.
Published in final edited form as: Ophthalmology. 2016 Feb 10;123(4):841–849. doi: 10.1016/j.ophtha.2015.11.021

Table 3. Results of Crossover (Mixed-Effect Model) Analysis, Stratified by Visual Acuity at Baseline (Post hoc Analysis). Bevacizumab.

and Ranibizumab columns represent the estimated effect of the drug for a 3-month period, adjusted for period and baseline value. The Difference column represents the estimated difference between the two drugs.

Baseline visual acuity letter score Bevacizumab [95% CI] Ranibizumab [95% CI] Difference [95% CI] P-Value
Best-Corrected Visual Acuity, Change from Baseline (letters) Any (all eyes) 5.3 [3.2, 7.4] 6.6 [4.5, 8.7] 1.3 [0.07, 2.5] 0.039
≥ 69 letters 3.1 [0.2, 6.0] 3.6 [0.7, 6.5] 0.45 [−1.4, 2.3] 0.64
< 69 letters 6.9 [4.3, 9.4] 8.7 [6.2, 11.3] 1.9 [0.3, 3.5] 0.022
OCT Central Subfield Mean Thickness, Change from Baseline (μm) Any (all eyes) −89 [−116, −62] −137 [−164, −110] −48 [−65, −31] <0.001
≥ 69 letters −106 [−144, −68] −145 [−183, −108] −40 [−66, −14] 0.0032
< 69 letters −78 [−111, −45] −132 [−165, −99] −54 [−76, −31] < 0.001