Table 3.
miRNA affects DNA methylation as an epigenetic change contributing to ageing and cancer
| Authors | Type of disease | Type of miRNA | Target* | Finding/Suggestion for miRNA |
|---|---|---|---|---|
| Ng et al. (43) | Acute promyelocytic leukaemia | miRNA-34a | Kelch-like protein 17 (Actinfilin) Calmodulin-binding transcription activator 1 | Methylation of miRNA-34b/c may contribute to APL leukaemogenesis |
| miRNA-34b | Kelch-like protein 17 (Actinfilin) Tumor protein p73 (p53-related protein) | |||
| miRNA-34c | Kelch-like protein 17 (Actinfilin) PR domain zinc finger protein 16 | |||
| Xie et al. (44) | Hepatocellular carcinoma cancer | miRNA-34a | Kelch-like protein 17 (Actinfilin) Calmodulin-binding transcription activator 1 | DNA methylation might be involved in the inactivation of miRNA-34b in HCC |
| miRNA-34b | Kelch-like protein 17 (Actinfilin) Tumor protein p73 (p53-related protein) | |||
| miRNA-34c | Kelch-like protein 17 (Actinfilin) PR domain zinc finger protein 16 | |||
| Ko et al. (3) | Acute myeloid leukemia | miRNA-let-7a | Basement membrane-specific heparan sulfate proteoglycan core protein precursor | let-7a-3 methylation is a positive prognosticator for AML patients |
| Huang et al. (45) | Endometrial cancers | miRNA-203 | Msx2-interacting protein Macoilin AT-rich interactive domain-containing protein 1A | miRNA-203 methylation Level might represent a marker for the patients with endometrioid cancers |
| Verhoef et al.(46) | Cervical intraepithelial neoplasia grade 2 (CIN2) | miRNA-124a-2 | Arginine-glutamic acid dipeptide repeats protein retinoblastoma-associated factor 600 | DNA methylation of miRNA-124-2 on HPV-test-positive self-samples is non-inferior to cytology triage in the detection of CIN2 |
| Li et al. (47) | Non-small cell lung cancer cells (NSCLC) | miRNA-503 | Protein kinase C zeta type Vacuolar protein sorting-associated protein 13D | Epigenetic silencing of microRNA-503 regulates FANCA** expression in non-small lung cancer cell |
| Ben Gacem et al. (48) | Breast cancer | miRNA-124a-1 miRNA-124a-2 miRNA-124a-3 | Arginine-glutamic acid dipeptide repeats protein retinoblastoma-associated factor 600 | DNA methylation of miRNA-124a-1, miRNA-124a-2 and miR-124a-3 in breast cancer play a role in tumor growth and aggressiveness |
| Wang et al. (49) | Chronic lymphocytic leukemia (CLL) | miRNA-9-3 | Nuclear inhibitor of protein phosphatase 1 Eyes absent homolog 3 Zinc finger MYM-type protein 6 | miRNA-9-3 is a tumor suppressor miRNA frequently methylated, and hence is silenced in CLL |
| Yamada et al. (50) | Acute lymphoblastic leukaemia | miRNA-128a | Integrator complex subunit 11 | Induction of miRNA128a expression by DNA demethylation is a novel mechanism of resistance to Fas-mediated apoptosis |
| Nadal et al. (51) | Lung adenocarcinoma | miRNA-34b | Kelch-like protein 17 (Actinfilin) Tumor protein p73 (p53-related protein) | Epigenetic inactivation of miRNA-34b/c by DNA methylation has independent prognostic value in patients with early-stage lung adenocarcinoma |
| miRNA-34c | Kelch-like protein 17 (Actinfilin) PR domain zinc finger protein 16 | |||
| Xing et al. (52) | Hepatocellular carcinoma | miRNA-122 | Arginine-glutamic acid dipeptide repeats protein Msx2-interacting protein | DNA Methylation of miRNA-122 might be involved in the development of hepatocellular carcinoma |
| Zhang et al. (53) | Nickel-induced cancer | miRNA-203 | Msx2-interacting protein Macoilin AT-rich interactive domain-containing protein 1A | DNA methylationassociated silencing of tumor suppressor miRNAs contributes to the development of Nickelinduced cancer |
| Zhang et al. (54) | Colorectal cancer (CRC) | miRNA-126 | D site-binding protein Protein LAP2 Uncharacterized protein C10orf6 | DNA methylation-induced silencing of miRNA-126 contributes to tumor invasion and angiogenesis in CRC |
*; Predicted by target scan and **; Fanconi anemia complementation group A protein.