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. 2016 Apr 26;10(5):379–394. doi: 10.1080/19336950.2016.1180489

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© 2016 The Author(s). Published with license by Taylor & Francis Group, LLC

This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License http://creativecommons.org/licenses/by-nc/3.0/, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.

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Figure 7. — Chimeric Rem/Gem analyses of determinants required for α_1C-binding-dependent Ca_V1.2 inhibition. (A) FRET detection of interactions between YFP-α_1CNT and CFP-tagged Rem/Gem constructs. *P < 0.05 compared with CFP-FRB using one-way ANOVA and Bonferroni tests. Data are means ± SEM. (B) Left, J_peak─V relationships for α_1C + β_2a (▪, n = 6) and α_1C + β_2a + Gem-r (О, n = 4) channels. Data for α_1C + β_2a + Rem is reproduced for comparison (red line). Right, J_peak─V relationships for α_1C + β_2aTM (▪, n = 9) and α_1C + β_2aTM + Gem-r (О, n = 8) channels. Data for α_1C + β_2aTM + Rem is reproduced for comparison (red line). (C) Left, J_peak─V relationships for α_1C + β_2a (▪, n = 6) (data are same as in (B)) and α_1C + β_2a + r-Gem-r (▿, n = 7) channels. Data for α_1C + β_2a + Rem is reproduced for comparison (red line). Right, J_peak─V relationships for α_1C + β_2aTM (▪, n = 9) and α_1C + β_2aTM + r-Gem-r (▿, n = 10) channels. Data for α_1C + β_2aTM + Rem is reproduced for comparison (red line). (D) Left, J_peak─V relationships for α_1C + β_2a (▪, n = 6) (data are same as in (B)) and α_1C + β_2a + g-Rem (◊, n = 9) channels. Data for α_1C + β_2a + Rem is reproduced for comparison (red line). Right, J_peak─V relationships for α_1C + β_2aTM (▪, n = 9) (data are same as in (C)) and α_1C + β_2aTM + g-Rem (◊, n = 8) channels. Data for α_1C + β_2aTM + Rem is reproduced for comparison (red line). Data are means ± SEM.