Figure 6.

Summarized data depicting the dose-dependent effect of AITC or capsaicin on [Ca²⁺]_i in CMs obtained from WT, TRPA1^−/− or TRPV1^−/− mice ((A) and (B) respectively). Responses to ethanol alone (vehicle control) were normalized to 100% and considered the control response. Summarized data depicting the dose-dependent effect of the TRPA1 antagonist, HC-030031 or the TRPV1 antagonist, SB366791 on AITC- (100 µM) or capsaicin- (100 nM) induced increases in [Ca²⁺]_i. ((C)and (D)respectively). Responses to the AITC alone (100 µM) were normalized to 100% and considered the control response. n = experiments performed in CMs obtained from 6 separate mice. *P < 0.05 compared to vehicle treated (ethanol) control. Statistical analysis performed using one way analysis of variance and the Bonferroni post hoc test.