Skip to main content
. 2016 May 5;7(4):334–341. doi: 10.1080/19490976.2016.1182289

Figure 2.

Figure 2.

Caspase-1 and caspase-8 play redundant roles in neutrophils to induce disease in Pstpip2cmo mice. Here, we propose potential complexes that activate caspase-1 and caspase-8 to promote IL-1β cleavage in neutrophils and promote disease. Pstpip2cmo mice harbor pathogenic Prevotella, which promotes the upregulation of pro-IL-1β through yet-unknown toll-like receptors. (A) Caspase-1 processes pro-IL-1β in the inflammasome complex containing NLRP3 and ASC. Caspase-8 also functions in redundant complexes to process pro-IL-1β downstream of (B) TNFR1 and (C) Dectin-1.