Figure 7.

FGF13S markedly decrease the response to different frequency trains. Cells were held at −120 mV for 40 ms for 20 episodes at a variety of frequencies (0.5, 1, 2, 5 and 10 Hz). (A-D). Averages are summarized at variety of frequencies for cells expression of Nav1.5 with GFP (A) (n = 8), FGF13S (B) (n = 5), FGF13U (C) (n = 7), FGF13VY (D) (n = 6). (E) The level of inactivation of the Nav1.5 current was increased by co-expression of FGF13S at frequencies of 2, 5 and 10 Hz (*P<0.05, compared to GFP group).