Fig. 8.

Role of epoxy-oxylipins in the resolution phenotype. The resolution of zymosan-initiated inflammation involves monocytes, dendritic cells, and T- and B-cell recruitment and the differentiation of monocytes into resolution-type macrophages. In this process (as revealed by epoxI treatment and sEH^−/− mice), epoxy-oxylipins, most likely EETs, limit Ccl2 and Ccr2 expression, Ly6c^hi monocyte accumulation, and T- and B-cell recruitment and encourage the formation of mature phagocytic resolution macrophages. Ly6c^hi monocytes, Ly6c^lo monocytes, dendritic cells, and monocyte-derived and resident macrophages are all activated in the presence of epoxI.