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. Author manuscript; available in PMC: 2017 Aug 28.
Published in final edited form as: Cancer Lett. 2016 May 26;379(1):60–69. doi: 10.1016/j.canlet.2016.05.029

Figure 3. HEXIM1 restored sensitivity to the inhibitory effects of tamoxifen in a tamoxifen resistant cell line.

Figure 3

(A) Western blot analyses of HEXIM1 expression in MCF7 and MCF7/TOTR cells. MCF7/TOTR clone 1 cells were also treated with vehicle (DMSO), 5 mM HMBA, or 50 uM 4a1. (B) MCF7 or MCF7/TOTR (clone 1) or (C) MDA-MB-231, MDA-MB-468, MCF10A, and HBL-100 cells were treated as indicated for 7 days. MTT assays were then performed to assess proliferation. The right panel shows western blot analyses of HEXIM1 expression in MCF10A and HBL-100 cells. The figures are representative of 3 experiments. * p < 0.01 relative to DMSO treated cells.