Table 2. Median and interquartile range of concentration and MoM of PAPP-A and PlGF by gestational week (n = 398).
| Weeks | N = (%) | Median concentration (IQR) PAPP-A U/L | Median concentration (IQR) PlGF pg/L | MoM PAPP-A, median (IQR), adjusted for gestational age | MoM PAPP-A, median (IQR), adjusted for gestational age and weight | MoM PlGF-A, median (IQR), adjusted for gestational age |
|---|---|---|---|---|---|---|
| 8 | 31 (7.8) | 565 (310–980) | 22.15 (16.1–31.2)* | 4.62 (1.70–8.3) | 4.41 (1.57–7.90) | |
| 9 | 40 (10.1) | 972 (608–2285) | 23.6 (19.45–31.4) | 2.13 (1.32–4.75) | 2.52 (1.15–4.83) | 0.90 (0.74–1.20) |
| 10 | 80 (20.1) | 2210 (1410–3060) | 32.6 (25.3–45.0) | 2.20 (1.45–3.63) | 2.10 (1.34–3.35) | 1.14 (0.89–1.58) |
| 11 | 73 (18.3) | 3190 (1610–4920) | 38.7 (32.7–48.6) | 1.94 (0.98–3.18) | 1.97 (1.06–3.20) | 1.18 (0.98–1.48) |
| 12 | 75 (18.8) | 5120 (2830–7570) | 48.8 (35.8–61.9) | 2.16 (1.17–3.6) | 2.25 (1.12–3.39) | 1.26 (0.94–1.63) |
| 13 | 99 (24.9) | 8240 (4080–13000) | 77.7 (59.2–132) | 2.61(1.36–4.27) | 2.46 (1.38–3.85) | 1.73 (1.32–2.94) |
| Total | 2.30 (1.33–4.14) | 2.34 (1.24–3.97) | 1.25 (0.95–1.80) |
IQR = interquartile range.
* n = 34, as statistical outliers could not be excluded as PlGF MoM values were available from week 9 onwards.
Compared to the median MoM values of the reference population (1 by default), the PAPP-A median MoM was 2.30 (1.33–4.14), and 2.34 (1.24–3.97) after weight correction. The median PlGF MoM was 1.25 (0.95–1.80) (Table 3).