Fig. 2.

Detail of the ventricles of a healthy subject. From left to right, original image without lesions (a). Synthetic lesion mask using the registered lesion mask from the “severe” MS phantom from the BrainWeb dataset (b). Brain mask obtained using STEPS overlaying synthetic lesion image (c). Euclidean distance from each voxel to the closest healthy voxel without defining priors (d). Euclidean distance to the closest healthy voxel using as prior mask the STEPS mask (e). Filling results without and with priors (f - g).