Table 2.
Least-Square Means for Postrandomization Blood Pressure Achieved by Treatment Group
| Intensive Treatment
|
Standard Treatment
|
Difference Between Groups, Mean (95% CI)a | P Value for Interactionb | |||
|---|---|---|---|---|---|---|
| No. | Mean (95% CI) | No. | Mean (95% CI) | |||
| Systolic blood pressure | ||||||
|
| ||||||
| Overall, mm Hg | 1317 | 123.4 (123.0–123.9)c | 1319 | 134.8 (134.3–135.2)c | 11.4 (10.8–11.9) | |
|
| ||||||
| Frailty statusd | ||||||
|
| ||||||
| Fit | 159 | 121.4 (120.3–122.5) | 190 | 134.9 (133.9–135.9) | 13.5 (12.0–15.0) | .01 |
|
| ||||||
| Less fit | 711 | 123.3 (122.8–123.9) | 745 | 134.7 (134.1–135.2) | 11.3 (10.6–12.1) | |
|
| ||||||
| Frail | 440 | 124.3 (123.5–125.0) | 375 | 135.0 (134.2–135.8) | 10.8 (9.7–11.8) | |
|
| ||||||
| Gait speed | ||||||
|
| ||||||
| Speed ≥0.8 m/s | 880 | 123.3 (122.8–123.8) | 893 | 134.6 (134.0–135.1) | 11.3 (10.6–11.9) | .67 |
|
| ||||||
| Speed <0.8 m/s | 371 | 123.8 (123.0–124.6) | 369 | 135.2 (134.4–136.0) | 11.4 (10.4–12.5) | |
|
| ||||||
| Missing | 66 | 123.5 (121.7–125.2) | 57 | 136.0 (134.0–137.9) | 12.5 (9.9–15.1) | |
|
| ||||||
| Diastolic blood pressure | ||||||
|
| ||||||
| Overall, mm Hg | 1317 | 62.0 (61.7–62.3)c | 1319 | 67.2 (66.8–67.5)c | 5.2 (4.7–5.6) | |
|
| ||||||
| Frailty statusd | ||||||
|
| ||||||
| Fit | 159 | 61.9 (61.1–62.8) | 190 | 67.4 (66.7–68.2) | 5.5 (4.3–6.6) | .07 |
|
| ||||||
| Less fit | 711 | 62.1 (61.7–62.6) | 745 | 67.6 (67.2–68.0) | 5.4 (4.9–6.0) | |
|
| ||||||
| Frail | 440 | 61.8 (61.3–62.3) | 375 | 66.2 (65.6–66.8) | 4.4 (3.6–5.1) | |
|
| ||||||
| Gait speed | ||||||
|
| ||||||
| Speed ≥0.8 m/s | 880 | 62.0 (61.6–62.3) | 893 | 67.2 (66.9–67.6) | 5.3 (4.8–5.8) | .08 |
|
| ||||||
| Speed <0.8 m/s | 371 | 62.3 (61.7–62.8) | 369 | 66.8 (66.2–67.4) | 4.6 (3.8–5.4) | |
|
| ||||||
| Missing | 66 | 61.4 (60.1–62.7) | 57 | 68.2 (66.7–69.6) | 6.8 (4.8–8.8) | |
a
P < .001 for all mean differences.
b
From amixed model.
c
Least-square means for blood pressure estimated from mixed model conditioned on baseline blood pressure.
d
Frailty status classified using 37-item frailty index (FI): fit (FI ≤0.10), less fit (FI >0.10 to ≤0.21), or frail (FI >0.21).