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Flowchart showing the final histopathologic assessment of random and targeted biopsies.HDE, high-definition endoscopy; pCLE, probe-based laser endomicroscopy; HDE-identified lesions, dysplasia suspicion only in HDE, in pCLE- no dysplasia suspicion; pCLE-identified lesions, dysplasia suspicion only in pCLE, in HDE- no dysplasia suspicion; HDE + pCLE-identified lesions, dysplasia suspicion in both: HDE and pCLE.
