Skip to main content
. Author manuscript; available in PMC: 2017 Mar 30.
Published in final edited form as: J Am Chem Soc. 2016 Mar 18;138(12):4260–4266. doi: 10.1021/jacs.6b01578

Table 2.

Substrate Scope in K~Pd(NIXANTPHOS)-Catalyzed C-3 Arylationa

graphic file with name nihms787858f8.jpg
a

Reactions conducted on a 0.1 mmol scale using 1.2 equiv of 1, 2.5 equiv of KN(SiMe3)2, and 1 equiv of 2 at 0.1 M. Isolated yield after chromatographic purification. The C-3:diarylation ratios in parentheses were determined by 1H NMR spectroscopy of the crude reaction mixtures.

b

45 °C.

c

2 equiv of KN(SiMe3)2.

d

Reaction conducted on a 0.3 mmol scale.

e

3 equiv of KN(SiMe3)2.

f

10 mol % Pd(OAc)2 and 15 mol % NIXANTPHOS.

g

Yield determined by 1H NMR spectroscopy of the crude reaction mixtures.

h

KOtBu was used as base.

i

2.5 equiv of 1f.

j

CPME was used as solvent.