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. Author manuscript; available in PMC: 2017 Mar 30.
Published in final edited form as: J Am Chem Soc. 2016 Mar 18;138(12):4260–4266. doi: 10.1021/jacs.6b01578

Table 3.

Substrate Scope in (Crown)Li~Pd(NIXANTPHOS)-Catalyzed Benzylic Arylationa

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a

Reactions conducted on a 0.1 mmol scale using 1.2 equiv of 1, 2.5 equiv of LiN(SiMe3)2, 5 equiv of 12-crown-4, and 1 equiv of 2 at 0.1 M. Isolated yield after chromatographic purification.

b

1a:LiN-(SiMe3)2:12-crown-4:2 = 2:1.5:3:1.

c

1a:LiN(SiMe3)2:12-crown-4:2 = 2:2:4:1.

d

1a:LiN(SiMe3)2:12-crown-4:2 = 1:2:4:2.

e

1a:LiN-(SiMe3)2:12-crown-4:2 = 1.2:3:6:1.

f

NaOtBu was used as base.

g

CPME was used as solvent.