. Author manuscript; available in PMC: 2017 Aug 1.

Published in final edited form as: J Am Geriatr Soc. 2016 Jul 5;64(8):1583–1591. doi: 10.1111/jgs.14222

Table 3.

Gain in Years of Disease-Free Survival of LGP and NECS Subjects

Disease	Males		Females		NECS.C Females vs. Males	LGP.C Females vs. Males	NECS.R Females vs. Males	LGP.R Females vs. Males
Disease	NECS.C vs. NECS.R	LGP.C vs. LGP.R	NECS.C vs. NECS.R	LGP.C vs. LGP.R	NECS.C Females vs. Males	LGP.C Females vs. Males	NECS.R Females vs. Males	LGP.R Females vs. Males
Cancer (p = 0.20)	30.0 (26.5, 33.4)	18.5 (13.4, 23.7)	25.3 (20.3, 29.4)	22.0 (18.5, 25.4)	1.4 (−1.2, 4.0)	−0.2 (−5.2, 4.7)	6.2 (1.4, 11.4)	−3.6 (−7.4, 0.0)
CVD (p = 0.25)	23.5 (19.8, 27.0)	17.6 (12.9, 22.5)	17.9 (12.3, 22.6)	12.1 (7.1, 16.7)	1.9 (−0.7, 4.4)	6.2 (1.2, 10.9)	7.5 (2.1, 13.5)	11.7 (7.1, 16.6)
HTN (p = 0.25)	34.9 (31.6, 38.1)	26.5 (21.4, 31.7)	29.1 (25.9, 32.1)	16.7 (13.2, 20.2)	−5.1 (−7.9, −2.4)	−7.3 (−12.9, −2.0)	0.6 (−2.9, 4.2)	2.5 (−0.6, 5.5)
Osteoporosis (p = 0.25)	15.5 (8.8, 21.2)	6.7 (1.2, 12.3)	21.6 (18.5, 24.5)	12.3 (8.0, 16.5)	−11.7 (−14.5, −9.1)	−7.6 (−12.3 −2.9)	−17.9 (−24.5, −12.1)	−13.2 (−18.2, −7.9)
Stroke (p = 0.10)	22.3 (17.1, 26.7)	6.9 (−0.5, 14.4)	19.4 (12.1, 24.6)	2.2 (−3.6, 9.0)	−0.3 (−3.0, 2.3)	−2.9 (−8.0, 2.4)	2.6 (−4.3, 10.7)	1.8 (−7.1, 9.9)
Morbidity (p = 0.20)	24.2 (21.8, 26.5)	21.3 (17.7, 25.2)	18.4 (16.3, 20.4)	18.0 (15.7, 20.4)	−4.6 (−6.5, −2.7)	−2.5 (−6.7, 1.4)	1.2 (−1.3, 3.7)	0.8 (−1.2, 2.7)

Years delay and 95% credible intervals (in parenthesis) to have a proportion p of the group affected with disease. The delays were estimated using Weibull regression and the formula $age = {(l n (\frac{1}{p}) / λ)}^{\frac{1}{ν}}$ where λ and ν are the parameters of the hazard function h(age) = λν(age^ν⁻¹) (see Supplementary Material for details). The proportion p used for each disease is reported in column 1. Columns report gain in years of disease-free survival in male centenarians from the NECS relative to male referents (NECS.C vs. NECS.R); in male centenarians from the LGP relative to male referents (LGP.C vs. LGP.R); female centenarians from the NECS relative to male referents (NECS.C vs. NECS.R); in female centenarians from the LGP relative to male referents (LGP.C vs. LGP.R);in female centenarians from the NECS relative to male centenarians from NECS; in female centenarians from the LGP relative to male centenarians from LGP; in female referents from the NECS relative to male referents from NECS; and in female referents from the LGP relative to male referents from LGP. NECS = New England Centenarian Study; LGP = Longevity Genes Project.