Table 3.
Intra- and inter-patient mean sperm epigenetic differences (ΔM-values)
| Genomic Regiona | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Genome | Island | Shore | Shelf | TSS1500 | TSS200 | 5′UTR | 1st Exon | Body | 3′UTR | |||
| Global CpGs | Intra | ΔM-value b | −0.0462 (0.0049) |
−0.0575 (0.0215) |
−0.0710 (0.0153) |
−0.0201 (0.0094) |
−0.0592 (0.0140) |
−0.0427 (0.0169) |
−0.0426 (0.0088) |
−0.0465 (0.0147) |
−0.0424 (0.0046) |
−0.0365 (0.0042) |
| |ΔM-value|b | 0.3065 (0.0099) |
0.3029 (0.0082) |
0.3241 (0.0130) |
0.2946 (0.0096) |
0.3098 (0.0094) |
0.2856 (0.0064) |
0.2967 (0.0074) |
0.2974 (0.0072) |
0.3079 (0.0106) |
0.3049 (0.0104) |
||
| Inter | |ΔM-value|b | 0.4038 (0.0062) |
0.3779 (0.0097) |
0.4346 (0.0102) |
0.3816 (0.0035) |
0.3974 (0.0080) |
0.3528 (0.0069) |
0.3755 (0.0061) |
0.3727 (0.0077) |
0.4056 (0.0056) |
0.4023 (0.0050) |
|
| Imprinted CpGs | Intra | ΔM-value b | −0.0616 (0.0093) |
−0.0810 (0.0260) |
−0.0785 (0.0203) |
−0.0220 (0.0190) |
−0.0811 (0.0264) |
−0.0613 (0.0204) |
−0.0696 (0.0120) |
−0.0815 (0.0303) |
−0.0498 (0.0085) |
−0.0780 (0.0139) |
| |ΔM-value|b | 0.3228 (0.0137) |
0.3257 (0.0139) |
0.3445 (0.0201) |
0.2968 (0.0117) |
0.3286 (0.0161) |
0.3081 (0.0103) |
0.3237 (0.0144) |
0.3326 (0.0147) |
0.3230 (0.0141) |
0.3448 (0.0210) |
||
| Inter | |ΔM-value|b | 0.4264 (0.0100) |
0.4142 (0.0165) |
0.4718 (0.0163) |
0.3873 (0.0046) |
0.4255 (0.0165) |
0.3788 (0.0102) |
0.4061 (0.0110) |
0.4214 (0.0164) |
0.4352 (0.0080) |
0.4641 (0.0224) |
|
a
probe genomic location are provided in the annotation file supplied by Illumina
b
values are reported as the mean of the mean patient methylation difference and the mean square between