Table 4.
The average epigenetic difference (M-values) observed from semen samples collected either within or beyond 75 days from the same patient.
| Genomic Regiona | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Genome | Island | Shore | Shelf | TSS1500 | TSS200 | 5′UTR | 1st Exon | Body | 3′UTR | |||
| Global CpGs | < 75 days |
ΔM-valueb | −0.0276 (0.0061) |
0.0062 (0.0179) |
−0.0231 (0.0122) |
−0.0595 (0.0119) |
−0.0093 (0.0125) |
0.0050 (0.0168) |
−0.0117 (0.0097) |
−0.0038 (0.0147) |
−0.0437 (0.0074) |
−0.0473 (0.0057) |
| |ΔM-value|b | 0.3038 (0.0063) |
0.3005 (0.0045) |
0.3120 (0.0062) |
0.3092 (0.0112) |
0.3051 (0.0051) |
0.2899 (0.0040) |
0.2998 (0.0049) |
0.3005 (0.0044) |
0.3087 (0.0082) |
0.3074 (0.0089) |
||
| > 75 days |
ΔM-valueb | −0.0648 (0.0021) |
−0.1212 (0.0135) |
−0.1189 (0.0113) |
0.0193 (0.0022) |
−0.1092 (0.0082) |
−0.0903 (0.0097) |
−0.0736 (0.0044) |
−0.0891 (0.0087) |
−0.0412 (0.0010) |
−0.0258 (0.0017) |
|
| |ΔM-value|b | 0.3092 (0.0119) |
0.3052 (0.0106) |
0.3361 (0.0173) |
0.2800 (0.0060) |
0.3146 (0.0120) |
0.2813 (0.0077) |
0.2935 (0.0087) |
0.2942 (0.0087) |
0.3070 (0.0112) |
0.3025 (0.0102) |
||
| Imprinted CpGs | < 75 days |
ΔM-valueb | −0.0338 (0.0081) |
−0.0095 (0.0157) |
−0.0221 (0.0111) |
−0.0689 (0.0278) |
−0.0014 (0.0139) |
0.0023 (0.0189) |
−0.0253 (0.0083) |
−0.0075 (0.0208) |
−0.0574 (0.0125) |
−0.0306 (0.0027) |
| |ΔM-value|b | 0.3134 (0.0074) |
0.3110 (0.0054) |
0.3218 (0.0080) |
0.3128 (0.0123) |
0.3105 (0.0058) |
0.3022 (0.0041) |
0.3121 (0.0069) |
0.3164 (0.0061) |
0.3204 (0.0102) |
0.3197 (0.0099) |
||
| > 75 days |
ΔM-valueb | −0.0893 (0.0073) |
−0.1525 (0.0218) |
−0.1350 (0.0197) |
0.0250 (0.0026) |
−0.1609 (0.0218) |
−0.1250 (0.0104) |
−0.1139 (0.0098) |
−0.1555 (0.0237) |
−0.0421 (0.0028) |
−0.1254 (0.0183) |
|
| |ΔM-value|b | 0.3323 (0.0175) |
0.3404 (0.0196) |
0.3673 (0.0277) |
0.2809 (0.0086) |
0.3468 (0.0231) |
0.3139 (0.0147) |
0.3353 (0.0192) |
0.3488 (0.0204) |
0.3256 (0.0155) |
0.3699 (0.0273) |
||
a
probe genomic location are provided in the annotation file supplied by Illumina
b
values are reported as the mean of the mean patient methylation difference and the mean square between