Table 6.
Intra- and inter-patient mean sperm epigenetic differences (ΔM-values) by BMI classification.
| Genomic Regiona | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Genome | Island | Shore | Shelf | TSS1500 | TSS200 | 5′UTR | 1st Exon | Body | 3′UTR | |||
| BMI < 24 | Intra | ΔM-value b | −0.0320 (0.0011) |
−0.0406 (0.0049) |
−0.0472 (0.0055) |
−0.0098 (0.0009) |
−0.0434 (0.0031) |
−0.0331 (0.0020) |
−0.0307 (0.0012) |
−0.0308 (0.0023) |
−0.0224 (0.0004) |
−0.0298 (0.0003) |
| |ΔM-value|b | 0.2306 (0.0016) |
0.2286 (0.0020) |
0.2436 (0.0030) |
0.2235 (0.0004) |
0.2332 (0.0016) |
0.2131 (0.0005) |
0.2225 (0.0007) |
0.2237 (0.0009) |
0.2328 (0.0017) |
0.2310 (0.0013) |
||
| Inter | |ΔM-value|b | 0.3087 (0.0010) |
0.2672 (0.0014) |
0.3288 (0.0013) |
0.3003 (0.0005) |
0.2951 (0.0008) |
0.2515 (0.0004) |
0.2755 (0.0006) |
0.2673 (0.0007) |
0.3133 (0.0012) |
0.3079 (0.0011) |
|
| BMI 24 – 30 | Intra | ΔM-value b | −0.0189 (0.0082) |
−0.0095 (0.0276) |
−0.0137 (0.0172) |
−0.0285 (0.0105) |
−0.0127 (0.0196) |
−0.0056 (0.0267) |
−0.0165 (0.0152) |
−0.0185 (0.0224) |
−0.0221 (0.0070) |
−0.0260 (0.0055) |
| |ΔM-value|b | 0.2848 (0.0048) |
0.2970 (0.0050) |
0.2952 (0.0049) |
0.2730 (0.0053) |
0.2933 (0.0045) |
0.2845 (0.0040) |
0.2876 (0.0044) |
0.2943 (0.0048) |
0.2832 (0.0055) |
0.2785 (0.0053) |
||
| Inter | |ΔM-value|b | 0.4167 (0.0038) |
0.4009 (0.0083) |
0.4434 (0.0051) |
0.4014 (0.0023) |
0.4157 (0.0061) |
0.3850 (0.0080) |
0.4030 (0.0058) |
0.4039 (0.0078) |
0.4154 (0.0028) |
0.4133 (0.0026) |
|
| BMI > 30 | Intra | ΔM-value b | −0.1107 (0.0004) |
−0.1600 (0.0339) |
−0.1982 (0.0081) |
−0.0197 (0.0289) |
−0.1579 (0.0127) |
−0.1173 (0.0247) |
−0.1020 (0.0087) |
−0.1140 (0.0237) |
−0.1030 (0.0035) |
−0.0631 (0.0101) |
| |ΔM-value|b | 0.4439 (0.0016) |
0.4117 (0.0034) |
0.4794 (0.0061) |
0.4255 (0.0046) |
0.4395 (0.0025) |
0.3840 (0.0015) |
0.4107 (0.0005) |
0.4007 (0.0016) |
0.4490 (0.0020) |
0.4475 (0.0018) |
||
| Inter | |ΔM-value|b | 0.4729 (0.0088) |
0.4557 (0.0146) |
0.5273 (0.0177) |
0.4168 (0.0024) |
0.4655 (0.0119) |
0.3977 (0.0066) |
0.4233 (0.0060) |
0.4261 (0.0084) |
0.4745 (0.0081) |
0.4640 (0.0064) |
|
a
probe genomic location are provided in the annotation file supplied by Illumina
b
values are reported as the mean of the mean patient methylation difference and the mean square between