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. Author manuscript; available in PMC: 2017 Sep 1.
Published in final edited form as: Pain. 2016 Sep;157(9):2068–2080. doi: 10.1097/j.pain.0000000000000612

Figure 2. Effects of TSP4 on biophysical properties of HVA VGCCs.

Figure 2

A, TSP4 treatment had no effect on activation voltage (left panel). TSP4 decreased Gmax but not V1/2 or slope factors (n=9 for control and n=7 for TSP4 treatment). B, TSP4 treatment shifted the inactivation curve (left panel) to more positive voltages, but had no effect on the slope factor (right panel; n = 7 for control, n = 6 for TSP4, * P < 0.05 by Student’s t test.). C, TSP4 increased current inactivation during sustained depolarization from holding at −100mV, shown in sample traces with depolarization to −10mV (left panel), τ of inactivation during 2s of persistent depolarization (middle panel) and the ratio of current loss during 2s of persistent depolarization (right panel; n = 10 for vehicle control, n = 9 for TSP4). * P < 0.05 by Student’s t test or Tukey post hoc analysis following 2-way repeated measures ANOVA.