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. Author manuscript; available in PMC: 2017 Oct 1.
Published in final edited form as: Biol Psychiatry. 2016 Feb 17;80(7):534–540. doi: 10.1016/j.biopsych.2016.02.012

Figure 2.

Figure 2

Pharmacological inactivation of lOFC bidirectionally modulated the expression of avoidance at test. A. Experimental protocol separating rats based on freezing levels at the start of Ext-RP. B. Top: Infusions of fluorescent muscimol (MUS) into lOFC. Orange areas represent the minimum (dark) and the maximum (light) spread of MUS. Bottom: Representative micrograph showing a MUS infusion into lOFC. C. In high freezing rats (likely to fail Ext-RP), inactivation of lOFC reduced persistent avoidance without reducing freezing levels (Sal, n=5; Mus, n=7). D. In low freezing rat (likely to succeed in Ext-RP), inactivation of lOFC induced persistent avoidance without increasing freezing levels (Sal, n=10; Mus, n=10). Ext-RP data shown in blocks of three trials. All data are shown as mean ± SEM. **p<0.01.