Table 1.
Parameters derived from non-linear (G, P1, P2, HR range, G, and BP50) and linear (slope bradycardia and slope tachycardia) regression analysis of the baroreflex in animals treated with vehicle or losartan and subjected to RRS or CVS.
| Group | G (bpm/mmHg) | P1 (Δbpm) | P2 (Δbpm) | HR range (bpm) | BP50 (ΔmmHg) | Slope Bradycardia (bpm/mmHg) | Slope Tachycardia (bpm/mmHg) |
|---|---|---|---|---|---|---|---|
| Vehicle | |||||||
| Control | -2.1 ± 0.2 | -74 ± 5 | 134 ± 8 | 202 ± 6 | -1.3 ± 5 | -2.3 ± 0.2 | -3.2 ± 0.5 |
| RRS | -1.2 ± 0.2∗ | -59 ± 6 | 94 ± 8∗ | 157 ± 5∗ | -4.2 ± 4 | -1.7 ± 0.2 | -2.6 ± 0.4 |
| CVS | -1.2 ± 0.2∗ | -66 ± 6 | 96 ± 9∗ | 164 ± 12 | -2.1 ± 3 | -2.4 ± 0.3 | -2.5 ± 0.5 |
| Losartan | |||||||
| Control | -2.3 ± 0.3 | -78 ± 9 | 109 ± 12 | 187 ± 11 | 1.0 ± 3 | -1.9 ± 0.3 | -2.7 ± 0.6 |
| RRS | -2.6 ± 0.2# | -89 ± 9 | 102 ± 11 | 199 ± 8# | 0.0 ± 2 | -2.6 ± 0.4 | -2.0 ± 0.6 |
| CVS | -1.8 ± 0.2# | -66 ± 9 | 115 ± 12 | 178 ± 18 | -5.4 ± 2 | -2.3 ± 0.3 | -3.0 ± 0.5 |
Values are mean ± SEM (n = 6: vehicle control, losartan control; n = 7: losartan CVS; n = 8: vehicle RRS, vehicle CVS, losartan RRS).
∗P < 0.05 versus control group within same condition, #P < 0.05 versus respective group vehicle. Two-way ANOVA followed by Bonferroni’s post hoc test.