Table 3.
Summary of the effects of RRS and CVS in animals treated with vehicle or losartan.
| Vehicle | Losartan | ||||
|---|---|---|---|---|---|
| RRS | CVS | RRS | CVS | ||
| Somatic parameters | |||||
| Body weight | – | ↓ | – | ↓ | |
| Heart weight | ↑ | ↑ | – | – | |
| Adrenal weight | – | – | – | – | |
| Thymus weight | – | – | – | – | |
| HPA axis | |||||
| Corticosterone | – | ↑ | – | ↑ | |
| Cardiovascular baseline | |||||
| Mean Arterial pressure | – | – | – | – | |
| Diastolic Arterial pressure | – | – | – | – | |
| Systolic Arterial pressure | – | – | ↓ | ↓ | |
| HR | – | – | – | – | |
| Autonomic activity | |||||
| Cardiac sympathetic activity | ↑ | – | – | ↑ | |
| Cardiac Vagal activity | ↓ | ↓ | – | – | |
| Vascular sympathetic activity | – | – | – | – | |
| Intrinsic HR | ↓∗ | ↓∗ | – | – | |
| Baroreflex bradycardia | – | – | – | – | |
| Baroreflex tachycardia | ↓ | ↓ | – | – | |
| Vascular function | |||||
| Pressor response to phenylephrine | – | – | – | – | |
| Depressor effect of acetylcholine | – | – | – | ||
| Depressor effect of Sodium nitroprusside | – | – | – | – | |
Up or down arrows indicate significant increase or decrease, respectively.
∗Statistically non-significant but relevant (decrease of ∼10%).