Table 1.
Physiological characteristics: group 1 (healthy elderly, single 50 mg dose)
| Variable | Mean ± SD Total sample (n = 20) |
Mean ± SD Men (n = 10) |
Mean ± SD Women (n = 10) |
|---|---|---|---|
| Age (years) | 68.7 ± 4.1 | 70.4 ± 5.1 | 67 ± 1.3 |
| CrCL (ml/min) | 80.5 ± 17.5 | 86.3 ± 18.2 | 74.4 ± 15.3 |
| Weight (kg) | 66.6 ± 9.1 | 73.7 ± 5.3 ** | 59.5 ± 6.1 |
| BMI (kg/m2) | 24.1 ± 2.4 | 25.2 ± 1.8 * | 22.9 ± 2.5 |
| Height (m) | 1.7 ± 0.1 | 1.7 ± 0.5 ** | 1.61 ± 0.5 |
| Creatinine (μmol/l) | 56 ± 10.2 | 61.1 ± 9.7 * | 51. 0 ± 8.4 |
| Cmax (ng/ml) | 64.0 ± 29.9 | 50.5 ± 25.4* | 77.5 ± 28.8 |
| Tmax (hours) | 2.1 ± 0.8 | 2.4 ± 0.7 | 1.8 ± 0.8 |
Values for men and women were compared using independent samples t tests)
CrCL estimated creatinine clearance (ml/min—converted to l/h for the purposes of model building), BMI body mass index (kg/m2), Cmax peak plasma concentration (ng/ml—converted to mg/l for the purposes of model building), Tmax time taken to achieve Cmax (hours)
*p < 0.05; **p < 0.01