Table 3.
Pharmacokinetic model estimates for group 1 and the combined (groups 1 and 2) sample
| Parameter (units) | Group 1 (n = 20) | Combined (n = 45) | ||
|---|---|---|---|---|
| Estimate | RSE (%) | Estimate | RSE (%) | |
| ka | 0.87 | 14 | 0.85 | 16 |
| Cl | 84 | 7 | 54.3 | 8 |
| β-Cl,weight | 0.75 | ne | 0.75 | ne |
| β-Cl,Age | ne | ne | −2.9 (p = 2.3e-007) | |
| V1 | 668 (Men) | 15 | 455 | 13 |
| 399 (Women) | 13 | |||
| β-V1, weight | 1 | ne | ne | ne |
| β-V1,Gender | −0.52 (p = 6.6e-005) | 25 | ne | ne |
| Q | 117 | 15 | 111 | 16 |
| β-Q,weight | 0.75 | ne | ne | ne |
| V2 population | 808 | 12 | 736 | 11 |
| β-V2,weight | 1 | ne | ne | ne |
| Random effect | ||||
| ω_ka% | 37 | 21 | 48 | 24 |
| ω_Cl% | 31 | 16 | 36 | 16 |
| ω_V1% | 42 | 21 | 43 | 27 |
| ω_Q% | 61 | 19 | 63 | 20 |
| ω_V2% | 50 | 17 | 46 | 18 |
| ω_Cl_V1% | 73 | 19 | 73 | 23 |
| ω_Cl_Q% | 68 | 21 | 60 | 29 |
| ω_V1_Q% | 51 | 48 | 73 | 23 |
| ω_Cl_V2% | 60 | 25 | 66 | 22 |
| ω_V1_V2% | 97 | 9 | 90 | 16 |
| ω_Q_V2% | 54 | 33 | 60 | 30 |
| Residual error | ||||
| σ (group 1)% | 13 | 5 | 13 | 6 |
| σ (group 2)% | – | – | 53 | 24 |
ka absorption constant, Cl apparent clearance from central compartment, V1 central volume of distribution, Q intercompartmental clearance, V2 peripheral volume of distribution, ω inter-individual variability (expressed as a percentage), σ residual unexplained variability (expressed as a percentage and separated on the basis of group), weight log transformed and centred around a standard 70 kg weight, age log transformed and centred around the mean, RSE relative standard error, ne not estimated