Table 1.
Mean (+SE) scores of the highway driving test, the AWLT and subjective measures per treatment, alone and with alcohol and summary of overall effects of treatment, alcohol and treatment × alcohol
| Highway driving | AWLT | Driving quality | |||||
|---|---|---|---|---|---|---|---|
| SDLP | SDSP | Immediate | Delayed | Pre-test | Post-test | Alertness | |
| No alcohol | |||||||
| Plac | 16.86 ± 0.56 | 2.15 ± 0.13 | 27.20 ± 1.24 | 8.62 ± 0.62 | 76.78 ± 5.34 | 72.13 ± 4.45 | 75.91 ± 3.68 |
| L-meq 2.5 | 17.03 ± 0.49 | 2.23 ± 0.11 | 26.70 ± 1.84 | 8.24 ± 0.83 | 76.22 ± 4.73 | 65.17 ± 4.37 | 78.42 ± 2.90 |
| L-meq 5.0 | 17.40 ± 0.69 | 2.19 ± 0.11 | 25.60 ± 1.51 | 8.19 ± 0.77 | 78.96 ± 4.37 | 64.39 ± 4.43 | 73.04 ± 3.11 |
| L-meq 10 | 18.46 ± 0.59* | 2.31 ± 0.12 | 24.40 ± 1.32 | 7.33 ± 0.52* | 71.91 ± 4.62 | 62.74 ± 4.54 | 68.67 ± 3.55 |
| Meq 10 | 17.19 ± 0.61 | 2.24 ± 0.13 | 24.30 ± 1.40 | 7.38 ± 0.66 | 75.30 ± 3.90 | 69.00 ± 3.48 | 75.39 ± 2.85 |
| With alcohol | |||||||
| Plac | 19.40 ± 0.72 | 2.43 ± 0.14 | 20.60 ± 1.24 | 5.38 ± 0.71 | 62.00 ± 6.12 | 64.48 ± 4.29 | 63.39 ± 3.81 |
| L-meq 2.5 | 19.68 ± 0.71 | 2.42 ± 0.14 | 21.55 ± 1.14 | 4.14 ± 0.69 | 51.83 ± 5.06 | 55.43 ± 5.24 | 58.71 ± 3.80 |
| L-meq 5.0 | 19.63 ± 0.76 | 2.46 ± 0.14 | 22.05 ± 1.26 | 4.86 ± 0.64 | 59.43 ± 5.53 | 61.22 ± 3.49 | 59.39 ± 4.16 |
| L-meq 10 | 20.81 ± 0.79⟡ | 2.52 ± 0.13 | 21.00 ± 1.15 | 3.90 ± 0.61 | 54.22 ± 5.36 | 59.17 ± 4.16 | 56.79 ± 4.07 |
| Meq 10 | 20.57 ± 0.7⟡ | 2.56 ± 0.12 | 21.65 ± 1.36 | 4.43 ± 0.73 | 55.39 ± 4.36 | 55.04 ± 3.03 | 56.94 ± 3.50 |
| N. total | 23 | 23 | 20 | 21 | 23 | 23 | 21 |
| ANOVA | |||||||
| Treatment | |||||||
| df | 4.88 | 4.88 | 4.76 | 4.80 | 4.88 | 4.88 | 4.80 |
| F | 4.30 | 0.85 | 0.99 | 2.52 | 0.95 | 1.27 | 1.79 |
| p | 0.007 | NS | NS | 0.048 | NS | NS | NS |
| Alcohol | |||||||
| df | 1.22 | 1.22 | 1.19 | 1.20 | 1.22 | 1.22 | 1.20 |
| F | 55.56 | 24.49 | 52.42 | 204.48 | 32.9 | 6.12 | 24.28 |
| p | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | 0.021 | <0.001 |
| Treatment × alcohol | |||||||
| df | 4.88 | 4.88 | 4.76 | 4.80 | 4.88 | 4.88 | 4.80 |
| F | 1.88 | 0.46 | 2.12 | 0.47 | 0.63 | 1.01 | 2.40 |
| p | NS | NS | NS | NS | NS | NS | NS |
Significant treatment, alcohol or treatment × alcohol effects are indicated in bold (p < 0.05). Asterisks indicate: significant differences from placebo, *p < 0.05 (after sdHBC); significant differences from placebo with alcohol, ⟡ p < 0.05 (after sdHBC)
Plac placebo, L-meq 2.5 l-mequitazine 2.5 mg, L-meq 5.0 l-mequitazine 5.0 mg, L-meq 10 l-mequitazine 10 mg, Meq 10 mequitazine 10 mg, NS not significant, df degrees of freedom, sdHBC step-down Holm-Bonferroni correction