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. 2016 Aug 18;7:309. doi: 10.3389/fimmu.2016.00309

Table 4.

Important synthetic antimicrobial proteins and peptides according to the endogenous compounds from which they are derived.

Origin Endogenous compounds Exogenous synthetic compounds
Bovine

  • Indolicidin

  • Bovine Lactoferrin (BLF)b

  • Omiganan pentahydrochloride (CLS001)

  • LTX-109
Porcine

  • Protegrin

  • (β-defensin 2 (pBD-2)

  • Iseganan (IB-367)

  • pBD-2a
Amphibian

  • Ranalexin

  • Magainin

  • Polymixin

  • Pexiganan (MSI-78)
Human

  • Human defensins

  • Cathelicidin

  • Bactericidal/permeability-increasing protein (BPI)

  • Lactoferrin (LF)

  • Brilacidin

  • N/A

  • rBPI21

  • Talactoferrin and LTX-109

aDenotes promising compounds currently in pre-clinical experimental stages, all other synthetic forms are in clinical trial stages.

bDenotes compounds in the endogenous form that have undergone human clinical trial.