Table 2. Association of known fasting insulin GWAS SNPs in the IGF1 region with fasting insulin levels without and with IGF1 levels as covariate in the model.

	CHS			FHS			RS			Meta			Discovery papera
	β	SE	P	β	SE	P	β	SE	P	β	SE	P	β	SE	P
Model1: ln(FI)~SNP+age+sex+BMI
rs2114912:G>T	0.020	0.024	0.41	−0.039	0.015	0.01	0.002	0.093	0.98	−0.021	0.013	0.09	−0.024	0.004	3.4 × 10−11
rs860598:G>A	0.007	0.020	0.72	−0.032	0.014	0.02	−0.072	0.076	0.34	−0.020	0.011	0.07	−0.021	0.003	6.9 × 10−10
rs35747:G>A	0.005	0.019	0.81	−0.032	0.014	0.02	−0.079	0.079	0.32	−0.021	0.011	0.06	−0.021	0.004	8.9 × 10−10
rs855213:A>G	0.005	0.020	0.81	−0.032	0.014	0.02	−0.072	0.076	0.34	−0.021	0.011	0.06	−0.021	0.004	1.0 × 10−9
rs35767:A>G	0.013	0.020	0.50	−0.031	0.015	0.04	−0.127	0.080	0.11	−0.017	0.012	0.15	−0.022	0.004	2.4 × 10−9
Model2: ln(FI)~SNP+age+sex+BMI+IGF1
rs2114912:G>T	0.018	0.024	0.45	−0.039	0.015	0.01	0.004	0.094	0.97	−0.022	0.013	0.08	NA	NA	NA
rs860598:G>A	0.004	0.020	0.85	−0.032	0.014	0.02	−0.071	0.077	0.36	−0.020	0.011	0.07	NA	NA	NA
rs35747:G>A	0.001	0.019	0.95	−0.033	0.014	0.02	−0.078	0.080	0.33	−0.022	0.011	0.05	NA	NA	NA
rs855213:A>G	0.002	0.020	0.94	−0.032	0.014	0.02	−0.071	0.077	0.36	−0.023	0.011	0.05	NA	NA	NA
rs35767:A>G	0.010	0.020	0.61	−0.031	0.015	0.04	−0.125	0.081	0.12	−0.018	0.012	0.13	NA	NA	NA

Abbreviations: CHS, Cardiovascular Health Study (n=1717); FHS, Framingham Heart Study (n=3293); RS, Rotterdam Study (n=140).

^aManning et al⁵ (n up to 51 750).