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. 2016 Feb 10;24(9):1337–1343. doi: 10.1038/ejhg.2016.4

Table 4. SKAT meta-analyses results for fasting insulin (BMI adjusted) from different subsets of rare (MAF <1%) SNPs in the IGF1 region.

Subset of rare SNVs No. of SNVs in subset P
Coding nonsynonymous 11 5.7 × 10−4
 Conditioned on GWAS variantsa   0.019
Coding nonsynonymous novelb 6 0.38
Noncoding predicted functionalc 188 0.38
Noncoding predicted functional novelb,c 156 0.16
a

Conditioned on proxies of rs2114912:G>T and rs35767:A>G.

b

Not known in dbSNP, 1000 genomes project, or ESP 6500.

c

Predicted transcription factor binding site (ENCODE ChipSeq, HMR) or DNAse hypersensitive site (ENCODE DHS) or ORegAnno regulatory variant or highly conserved (PhastCons).