Table 3. Top genes selected from association testing of BMD phenotypes with exome-sequencing variants.
| P-values | ||||||
|---|---|---|---|---|---|---|
| SKAT | MURAT | |||||
| Chr | Gene | No. of SNPs | FN | LS | FN and LS | ρv in MURAT |
| 2 | SNX17 | 34 | 1.02 × 10−1 | 2.46 × 10−9 | 3.05 × 10−8 | 0.5 |
| 6 | SLC17A5 | 42 | 2.39 × 10−6 | 4.43 × 10−2 | 6.12 × 10−7 | 0.6 |
| 20 | C20orf187 | 3 | 1.12 × 10−2 | 1.14 × 10−1 | 7.73 × 10−6 | 0 |
Abbreviations: BMD, bone mineral density; FN, femoral neck; LS, lumbar spine; MURAT, Multivariate Rare-Variant Association Test; SKAT, sequence kernel association test; SNP, single-nucleotide polymorphism.
Results with P-values ≤1 × 10−5 are shown. SKAT tests were not corrected for multiple comparisons. The last column reports the value of the correlation parameter ρv that gave the minimum P-value in the MURAT test.