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. 2016 Aug 18;4:16. doi: 10.1186/s40170-016-0156-6

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Simplified schematic of central carbon metabolism. Rectangular boxes contain branchpoint metabolite intermediates, and rounded rectangular boxes contain amino acid and fatty acid products that can be incorporated into biomass macromolecules. Arrows indicate carbon flux. Additional metabolic intermediates are not shown; instead, they are implicitly lumped into pools with displayed metabolites (e.g., fructose 6-phosphate with G6P)